A polymeric material - Malic acid butane-1, 4-diol-glycerol co-polyester (MBGC) was synthesized. The polymer was dissolved in volatile organic solvent (Ethyl acetate) to prepare coating solution. The coating solution is sprayed over the DS tablet in a small coating pan with continuous hot air flow. The coating pan is allowed to rotate until the solvent evaporated and the tablet dried. The percentage of drug release from dichlofenac sodium (DS) core and coated tablets (coated by Malic acid butane-1, 2-diol- glycerol co-polyester) in stimulated gastric fluid (pH = 1.2) and in stimulated intestinal fluid (pH = 7.4) was investigated and satisfactory result was obtained.
Authors: Md. Shah ruzzaman, Md. Saiful Islam, Md. Moinul Haque, Md. Shakhawat Hossain, Dr. Md. Abu Bakr
DOI: https://doi.org/10.14299/ijser.2015.03.007
Publish Year: 2015
