Reducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late-onset dementia, including Alzheimer's disease (AD), indicates a potential impact of multidomain lifestyle interventions on risk reduction. The positive results of the landmark multidomain Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) support such an approach. The World-Wide FINGERS (WW-FINGERS), launched in 2017 and including over 25 countries, is the first global network of multidomain lifestyle intervention trials for dementia risk reduction and prevention. WW-FINGERS aims to adapt, test, and optimize the FINGER model to reduce risk across the spectrum of cognitive decline-from at-risk asymptomatic states to early symptomatic stages-in different geographical, cultural, and economic settings. WW-FINGERS aims to harmonize and adapt multidomain interventions across various countries and settings, to facilitate data sharing and analysis across studies, and to promote international joint initiatives to identify globally implementable and effective preventive strategies.
Authors: Miia Kivipelto, Francesca Mangialasche, Heather M. Snyder, Ricardo Allegri, Sandrine Andrieu, Hidenori Arai, Laura D. Baker, Sylvie Belleville, Henry Brodaty, Sônia Maria Dozzi Brucki, Ismael Luis Calandri, Paulo Caramelli, Christopher Chen, Howard Chertkow, Effie Chew, Seong Hye Choi, Neerja Chowdhary, Lucía Crivelli, Rafael de la Torre, Yifeng Du, Tarun Dua, Mark A. Espeland, Howard Feldman, Maris Hartmanis, Tobias Hartmann, Megan Heffernan, Christiani Jeyakumar Henry, Chang Hyung Hong, Krister Håkansson, Takeshi Iwatsubo, Jee Hyang Jeong, Gustavo Jimenez‐Maggiora, Edward H. Koo, Lenore J. Launer, Jenni Lehtisalo, Francisco Lopera, Pablo Martínez‐Lage, Ralph N. Martins, Lefkos Middleton, José Luís Molinuevo, Manuel Montero‐Odasso, So Young Moon, Kristal Morales‐Pérez, Ricardo Nitríni, Haakon B. Nygaard, Yoo K. Park, Markku Peltonen, Chengxuan Qiu, Yakeel T. Quiroz, Rema Raman, Naren P. Rao, Vijayalakshmi Ravindranath, Anna Rosenberg, Takashi Sakurai, Rosa María Salinas, Philip Scheltens, Gustavo Sevlever, Hilkka Soininen, Ana Luisa Sosa, Cláudia Kimie Suemoto, Mikel Tainta, Lina Velilla, Yongxiang Wang, Rachel A. Whitmer, Xin Xu, Lisa J. Bain, Alina Solomon, Tiia Ngandu, María C. Carrillo
DOI: https://doi.org/10.1002/alz.12123
Publish Year: 2020
