We identified 4 novel genetic loci that implicate inflammatory and glial proliferative pathways in the development of WMH in addition to previously proposed ischemic mechanisms.
Authors: Benjamin F.J. Verhaaren, Stéphanie Debette, Joshua C. Bis, Jennifer A. Smith, M. Kamran Ikram, Hieab H.H. Adams, Ashley Beecham, Kumar B. Rajan, Lorna M. Lopez, Sandra Barral, Mark A. van Buchem, Jeroen van der Grond, Albert V. Smith, Katrin Hegenscheid, Neelum T. Aggarwal, Mariza de Andrade, Elizabeth J. Atkinson, Marian Beekman, Alexa Beiser, Susan H. Blanton, Eric Boerwinkle, Adam M. Brickman, R. Nick Bryan, Ganesh Chauhan, Christopher Chen, Vincent Chouraki, Anton J. M. de Craen, Fabrice Crivello, Ian J. Deary, Joris Deelen, Philip L. De Jager, Carole Dufouil, Mitchell S.V. Elkind, Denis A. Evans, Paul Freudenberger, Rebecca F. Gottesman, Vilmundur Guðnason, Mohamad Habes, Susan R. Heckbert, Gerardo Heiss, Saima Hilal, Edith Hofer, Albert Hofman, Carla A. Ibrahim‐Verbaas, David S. Knopman, Cora E. Lewis, Jiemin Liao, David C. Liewald, Michelle Luciano, Aad van der Lugt, Oliver Martinez, Richard Mayeux, Bernard Mazoyer, Mike A. Nalls, Matthias Nauck, Wiro J. Niessen, Ben A. Oostra, Bruce M. Psaty, Kenneth Rice, Jerome I. Rotter, Bettina von Sarnowski, Helena Schmidt, Pamela J. Schreiner, Maaike Schuur, Stephen Sidney, Sigurður Sigurdsson, P. Eline Slagboom, David J.M. Stott, John C. van Swieten, Alexander Teumer, Anna Maria Töglhofer, Matthew Traylor, Stella Trompet, Stephen T. Turner, Christophe Tzourio, Hae‐Won Uh, André G. Uitterlinden, Meike W. Vernooij, Jing Jing Wang, Tien Yin Wong, Joanna M. Wardlaw, B. Gwen Windham, Katharina Wittfeld, Christiane Wolf, Clinton B. Wright, Qiong Yang, Wei Zhao, Alex Zijdenbos, J. Wouter Jukema, Ralph L. Sacco, Sharon L. R. Kardia, Philippe Amouyel, Thomas H. Mosley, W. T. Longstreth, Charles DeCarli, Cornelia M. van Duijn, Reinhold Schmidt, Lenore J. Launer, Hans J. Grabe, Sudha Seshadri
DOI: https://doi.org/10.1161/circgenetics.114.000858
Publish Year: 2015
