Genetic variants in the <i>APOE</i> region are associated with the presence of BMB, most likely due to the <i>APOE</i> ε4 allele count related to a higher number of strictly lobar BMBs. Genetic predisposition to small vessel disease confers risk of BMB, indicating genetic overlap with other cerebral small vessel disease markers.
Authors: Maria J. Knol, Dongwei Lu, Matthew Traylor, Hieab H.H. Adams, José Rafael J Romero, Albert V. Smith, Myriam Fornage, Edith Hofer, Junfeng Liu, Isabel C. Hostettler, Michelle Luciano, Stella Trompet, Anne‐Katrin Giese, Saima Hilal, Erik B. van den Akker, Dina Vojinović, Shuo Li, Sigurður Sigurdsson, Sven J. van der Lee, Clifford R. Jack, Duncan Wilson, Pınar Yilmaz, Claudia L. Satizábal, David C. Liewald, Jeroen van der Grond, Christopher Chen, Yasaman Saba, Aad van der Lugt, Mark E. Bastin, B. Gwen Windham, Ching‐Yu Cheng, Lukas Pirpamer, Kejal Kantarci, Jayandra J. Himali, Qiong Yang, Zoë Morris, Alexa Beiser, Daniel J. Tozer, Meike W. Vernooij, Najaf Amin, Marian Beekman, Jia Yu Koh, David J. Stott, Henry Houlden, Reinhold Schmidt, Rebecca F. Gottesman, Andrew D. MacKinnon, Charles DeCarli, Vilmundur Guðnason, Ian J. Deary, Cornelia M. van Duijn, P. Eline Slagboom, Tien Yin Wong, Natalia S. Rost, J. Wouter Jukema, Thomas H. Mosley, David J. Werring, Helena Schmidt, Joanna M. Wardlaw, M. Arfan Ikram, Sudha Seshadri, Lenore J. Launer, Hugh S. Markus, for the Alzheimer's Disease Neuroimaging Initiative
DOI: https://doi.org/10.1212/wnl.0000000000010852
Publish Year: 2020
