Our findings identify the anterior thalamic radiation and forceps minor as strategic white matter tracts in which WMHs are most strongly associated with cognitive impairment in memory clinic patients with SVD. WMH volumes in individual tracts explained more variance in cognition than total WMH burden, emphasizing the importance of lesion location when addressing the functional consequences of WMHs.
Authors: J. Matthijs Biesbroek, Nick A. Weaver, Saima Hilal, Hugo J. Kuijf, M. Kamran Ikram, Xin Xu, Boon Yeow Tan, Narayanaswamy Venketasubramanian, Albert Postma, Geert Jan Biessels, Christopher Chen
DOI: https://doi.org/10.1371/journal.pone.0166261
Publish Year: 2016
