We analyzed white matter hyperintensities (WMH) in 3525 memory clinic patients from 11 cohorts The impact of WMH on cognition depends on location We identified four strategic white matter tracts A single strategic WMH score was derived from these four strategic tracts The strategic WMH score was an independent determinant of four cognitive domains.
Authors: Mirthe Coenen, Hugo J. Kuijf, Irene M.C. Huenges Wajer, Marco Duering, Frank J. Wolters, Evan F. Fletcher, Pauline Maillard, Alzheimer's Disease Neuroimaging Initiative, Frederik Barkhof, Josephine Barnes, Thomas Benke, Jooske M.F. Boomsma, Christopher Chen, Peter Dal‐Bianco, Anna Dewenter, Christian Enzinger, Michael Ewers, Lieza G. Exalto, Nicolai Franzmeier, Onno N. Groeneveld, Saima Hilal, Edith Hofer, Dineke L. Koek, Andrea B. Maier, Cheryl R. McCreary, Catarina S. Padilla, Janne M. Papma, Ross W. Paterson, Yolande A.L. Pijnenburg, Anna Rubinski, Reinhold Schmidt, Jonathan M. Schott, Catherine F. Slattery, Eric E. Smith, Rebecca M. E. Steketee, Carole H. Sudre, Esther van den Berg, Wiesje M. van der Flier, Narayanaswamy Venketasubramanian, Meike W. Vernooij, Xin Xu, Charles DeCarli, Geert Jan Biessels, J. Matthijs Biesbroek
DOI: https://doi.org/10.1002/alz.12827
Publish Year: 2022
