Higher global SUVR was associated with worse cognition in CIND and AD, but was augmented by an interaction between global SUVR and WMH only in CIND. This suggests that Aβ and CSVD are independent processes with a possible synergistic effect between Aβ and WMH in individuals with CIND. There was no interaction effect between Aβ and lacunes or CMBs. Therefore, in preclinical phases of AD, WMH should be targeted as a potentially modifiable factor to prevent worsening of cognitive dysfunction.
Authors: Francis N. Saridin, Saima Hilal, Steven G Villaraza, Anthonin Reilhac, Bibek Gyanwali, Tomotaka Tanaka, Mary C. Stephenson, Sin L. Ng, Henri A. Vrooman, Wiesje M. van der Flier, Christopher Chen
DOI: https://doi.org/10.1212/wnl.0000000000011029
Publish Year: 2020
