Key dementia etiologies may be associated with specific patterns of white matter hyperintensities (WMH). We related WMH locations to vascular risk and cerebral Aβ42 status in 11 memory clinic cohorts. Aβ42 positive status was associated with posterior WMH in splenium and posterior thalamic radiation. Vascular risk was associated with anterior and infratentorial WMH. Amyloid pathology and vascular risk have distinct signature WMH patterns.
Authors: J. Matthijs Biesbroek, Mirthe Coenen, Charles DeCarli, Evan Fletcher, Pauline Maillard, Alzheimer's Disease Neuroimaging Initiative, Frederik Barkhof, Josephine Barnes, Thomas Benke, Christopher Chen, Peter Dal‐Bianco, Anna Dewenter, Marco Duering, Christian Enzinger, Michael Ewers, Lieza G. Exalto, Nicolai Franzmeier, Saima Hilal, Edith Hofer, Huiberdina L. Koek, Andrea B. Maier, Cheryl R. McCreary, Janne M. Papma, Ross W. Paterson, Yolande A.L. Pijnenburg, Anna Rubinski, Reinhold Schmidt, Jonathan M. Schott, Catherine F. Slattery, Eric E. Smith, Carole H. Sudre, Rebecca M. E. Steketee, Charlotte E. Teunissen, Esther van den Berg, Wiesje M. van der Flier, Narayanaswamy Venketasubramanian, Vikram Venkatraghavan, Meike W. Vernooij, Frank J. Wolters, Xin Xu, Hugo J. Kuijf, Geert Jan Biessels
DOI: https://doi.org/10.1002/alz.13765
Publish Year: 2024
