Superficial CMBs are associated with larger morphometric brain measures, specifically white matter volume. This association is strongest in brains with fewer CMBs, suggesting that the CMB/CAA contribution to neurodegeneration may not relate to tissue loss, at least in early stages of disease.
Authors: Charles Beaman, Krystyna Kozii, Saima Hilal, Minghua Liu, Antonio Spagnolo‐Allende, Guillermo Polanco Serra, Christopher Chen, Ching‐Yu Cheng, Daniela Zambrano, Burak Arikan, Víctor J. Del Brutto, Clinton B. Wright, Xena Flowers, Sandra Leskinen, Tatjana Rundek, Amanda Mitchell, Jean Paul Vonsattel, Etty Cortés, Andrew F. Teich, Ralph L. Sacco, Mitchell S.V. Elkind, David Roh, José Gutierrez, on behalf of the Alzheimer's Disease Neuroimaging Initiative
DOI: https://doi.org/10.1212/wnl.0000000000200142
Publish Year: 2022
