RetiPhenoAge, a retinal aging marker, was studied in an Asian memory clinic cohort. Older RetiPhenoAge predicted future cognitive decline and incident dementia. It also linked to neuropathological markers, and plasma proteomic profiles of aging. UK Biobank replication found that RetiPhenoAge predicted 12-year incident dementia. Future studies should validate RetiPhenoAge as a prognostic biomarker for dementia.
Authors: Ming Ann Sim, Yih Chung Tham, Simon Nusinovici, Ten Cheer Quek, Marco Yu, Can Can Xue, Miao Li Chee, Qing Peng, Eugene S.J. Tan, Siew Pang Chan, Yuan Cai, Eddie Chong, Boon Yeow Tan, Narayanaswamy Venketasubramanian, Saima Hilal, Mitchell K.P. Lai, Hyungwon Choi, Mark Richards, Ching‐Yu Cheng, Christopher Chen
DOI: https://doi.org/10.1002/alz.14601
Publish Year: 2025
