The mitogenic activity in earthworms should be accompanied by antioxidative and antimicrobial activities during the healing or regeneration of their amputated part.These activities are achieved by bioactive macromolecules in their tissue and coelomic fluid.The antioxidative activity applied to prevent the cellular function from oxidative damage and assist cell multiplication.The antimicrobial activity prevents the wounded area from bacterial infection and enhances cell division.This review aims to promote cheap natural products of earthworms to be used widely in human medicine.Thus, we reviewed how to extract coelomic fluid, preparation of tissue homogenate (G-90) and application of mitogenic, antioxidative, antimicrobial activities on experimental animal rats, mice and rabbits.These products were efficient for hasty wound healing, the proliferation of damaged bone, boosting of immune cells and nerve cell regeneration without carcinogenic and mutagenic characteristics.Therefore, the biotechnological application of tissue homogenates and coelomic fluid should get due attention. INTRODUCTION:Earthworms are metamerically segmented organisms that belong to class Oligochaeta of phylum Annelida.The coelomic cavity of an earthworm is filled with coelomic fluid that oozes out through dorsal pore as a mechanism of defense in response to the body stress.Coelomic fluid from earthworms has been reported to possess several biological properties, like cytolytic, proteolytic, antimicrobial, hemolytic, haemagglutinin, tumorlytic, antiinflammatory, antioxidant, bacteriostatic, mitogenic and anticancer activities 1, 2 .
Authors: Kasahun Gudeta, Shailja Kumari, Ankeet Bhagat, JM. JULKA, Rohit Goyal, Mira Terezija, H, W Li, S Li, J Zhong, Z Zhu, J Liu, Wang, S Gupta, S Yadav, R Joskov, M ilerov, P Prochzkov, M Bilej, M Grdisa, M Popovic, T Hrzenjak, E Cooper, T Hrzenjak, M Grdia, M Hrzenjak, D Kobrehel, S Levanat, M Jurin, T Hrzenjak, W Li, S Li, J Zhong, Z Zhu, J Liu, Wang, W Li, Wang Sun, Z, Y Yang, H Hu, W Wang, X Duan, S Luo, Wang Sun, Y, H Mihara, H Sumi, T Yoneta, H Mizumoto, R Ikeda, M Seiki, M Maruyama, M Grdia, M Popovi, T Hrenjak, Y Fu, K Chen, Y Chen, C Yao, S Wei, X Yin, Y Kou, B Jiang, G Goodarzi, D Qujeq, M Elmi, F Feizi, Fathai, I Plavin, M Velki, S Eimovi, K Vrandei, J osi, R Joskov, M ilerov, P Prochzkov, M Bilej, M Grdisa, A Mikecin, T Hrzenjak, T Gillies, C Cabernard, T Chew, C Lorthongpanich, W Ang, B Knowles, D Solter, M Wilkinson, J Millar, L Bgre, I Meskiene, E Heberle-Bors, H Hirt, E Subramanian, D Sudalaimani, J Christyraj, J Christyraj, K Renganathan, S Krishnan
DOI: https://doi.org/10.13040/ijpsr.0975-8232.11(11).5298-07
Publish Year: 2020
