We review the role of E-cadherin in cancer progression, and its therapeutic restoration as a strategy to suppress metastasis. We subsequently discuss E-cadherin upregulating drugs, proposing a schema for restoring E-cadherin by targeting its epigenetic and transcriptional regulators. These pathways will likely provide significant future treatment breakthroughs against cancer metastasis.
Authors: Eric Howard, KD Camm, Y. C. Wong, X. Wang
DOI: https://doi.org/10.2174/138955708784223521
Publish Year: 2008
