Sirtuins are key players for maintaining cellular homeostasis and are often deregulated in different human diseases. <i>SIRT7</i> is the only member of mammalian sirtuins that principally resides in the nucleolus, a nuclear compartment involved in ribosomal biogenesis, senescence, and cellular stress responses. The ablation of <i>SIRT7</i> induces global genomic instability, premature ageing, metabolic dysfunctions, and reduced stress tolerance, highlighting its critical role in counteracting ageing-associated processes. In this review, we describe the molecular mechanisms employed by <i>SIRT7</i> to ensure cellular and organismal integrity with particular emphasis on <i>SIRT7</i>-dependent regulation of nucleolar functions.
Authors: Poonam Kumari, Shahriar Tarighi, Thomas Braun, Alessandro Ianni
DOI: https://doi.org/10.3390/genes12091361
Publish Year: 2021
