The aim of this study is to compare histopathologically the protective effect of melatonin and amifostine on radiation induced renal damage. 50 female albino rats were divided into five groups: control, radiotherapy alone, radiotherapy+amifostine, radiotherapy+melatonin, radiotherapy+amifostine+melatonin. Intraperitoneal amifostine (200 mg/kg) and intraperitoneal melatonin (10 mg/kg) was administered to 30 minutes before irradiation. Rats were irradiated with a single dose of 8 Gy on whole body. At the end of the follow-up period, percentage of damaged glomeruli was determined by counting damaged glomeruli of kidney cortex as segmental or total necrosis for each animal. The protective effect of each agent has been shown, and there is an advantage in favor of melatonin (p = 0.005). Although there is not an advantage of adding amifostine to melatonin (p = 0.243), there is statistically significant better protective effect in amifostine+melatonin group when compared with amifostine alone (p = 0.003). The protective effect of melatonin on radiation induced acute
Authors: Alaattin Özen, Suat Çakına, Şule Parlar, Nukhet Kurkcu, Necdet Süt, Cem Uzal
Publish Year: 2013
