Abstract Background Radiation-induced nephropathy (RIN) is an impairment of function caused by ionizing radiation which develops after6-12 months as acute or after years as chronic period. Methods This paper aims to clarify, whether L-carnitine has a protective effect in the prevention of RIN in an infant rat model. Results Two-week-old forty male Wistar albino rats were divided into four groups such as control (C), L-carnitine alone (LC), irradiation alone (RT), and L-Carnitine before irradiation (L-carnitine + RT), injected with LC (300 mg/kg) i.p., 30 minutes before the irradiation. The rats in the RT and L-Carnitine + RT groups were irradiated individually with a single dose of 8 Gy. All animals underwent both Tc99m DTPA dynamic renal imaging and Tc99m DMSA static renal imaging at the end of three months follow-up period. Proximal tubular degeneration, tubular atrophy, interstitial fibrosis, and glomerular degeneration were assessed histopathologically. While the kidney damage caused by irradiation was shown in line with both scintigraphy and histopathology findings, it was shown that L-carnitine did not have any negative effects on the kidney. Also, we could not demonstrate the protective effect of L-carnitine on radiation-induced kidney damage, both scintigraphically and histopathologically. Conclusion Although kidney damage due to irradiation was created in infantile rats successfully, the protective effect of L-carnitine could not be demonstrated in our study.
Authors: Ruşen Coşar, Alaattin Özen, Gülay Durmuş Altun, Necdet Süt, Kamuran İbiş, Fulya Öz Puyan, Ülkü Korkmaz, Şule Parlar, Dilek Nurlu, Talar Özler
DOI: https://doi.org/10.21203/rs.3.rs-1531095/v1
Publish Year: 2022
