The aim of the present research study was to Formulate and Evaluate sustained release tablets of Cimetidine 500mg tablet using direct compression method. Nine formulations were prepared using different polymers like HPMC, Xanthan Gum and Sodium CMC. These Polymers were used in different proportion to control the released of the drug. All the formulations were evaluated of physicochemical tests. All the physicochemical characters of the formulated tablets were within the acceptable limits. The release pattern of the drug was observed over a period of 12 hours and determined the amount of drug by the UV-visible method. Dissolution data showed all formulations showed drug release for 12hrs. Among all the formulations C6 showed best drug release 99.08%. The optimized formulations were followed zero–order kinetics, korsmeyer –peppas and Higuchi models.
Authors: Uma S, Suresh Ch, Abeyram M. Nithin, A Sindhuja, Kamble Akanksha, Iftekhar MD, Sameer Khan
DOI: https://doi.org/10.30904/j.jpbr.2025.4840
Publish Year: 2025
