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Salivary and serum asprosin hormone levels in the 2018 EFP/AAP classification of periodontitis stages and body mass index status: a case-control study

Clinical Oral Investigations

Asprosin may be a useful parameter as a biomarker of periodontal disease progression. However, BMI status should be considered when evaluating asprosin levels in patients with periodontitis.

Authors: Sema Nur Sevinç Gül, Didem Özkal Emi̇noğlu, Esra Laloğlu, Tuğba Aydın, Alparslan Dilsiz
Publish Year: 2024
Serum asprosin levels are increased in patients with periodontitis and <scp>ST</scp>‐segment elevation myocardial infarction and correlated with periodontal parameters: A case–control study

Journal of Periodontal Research

The results of this study show that STEMI and periodontitis are associated with high asprosin levels. Since the risk of periodontitis is high in STEMI patients, periodontitis should also be considered when evaluating asprosin levels in STEMI patients.

Authors: Sema Nur Sevinç Gül, Oğuzhan Birdal, Esra Laloğlu
Publish Year: 2023
Effect of oral antiseptics on the viral load of SARS-CoV-2: A randomized controlled trial

Dental and Medical Problems

In the light of the data obtained in this study, there is insufficient evidence that gargling with HClO or PVP-I reduces viral load. Taken together, these findings imply no role for antiseptics in the transmission of SARS-CoV-2 by the aerosol generated during dental procedures, or more generally, SARS-CoV-2 infection control.

Authors: Sema Nur Sevinç Gül, Alparslan Dilsiz, İmran Sağlık, Nurten Nur Aydın
Publish Year: 2022
Evaluation of Biomechanical Effects of Mandible Arch Types in All-on-4 and All-on-5 Dental Implant Design: A 3D Finite Element Analysis

Journal of Functional Biomaterials

This study evaluates the biomechanical effects of different implant configurations in various mandibular arch types using finite element analysis (FEA). Stress distribution and deformation patterns were analyzed under different loading conditions in square, U-shaped, and V-shaped arches. The results indicate that increasing the number of implants generally reduces cortical bone stress, particularly in U and V arches, while implant-level stress tends to increase. Under molar loading, cortical bone stress in the square arch decreased by 16.9% (from 90.61 MPa to 75.27 MPa) with the All-on-5 system, while implant stress in the V arch dropped by 46.26% (from 142.35 MPa to 76.5 MPa). Additionally, the cantilever effect in All-on-4 configurations resulted in higher stress on the prosthesis and implants, particularly in V arches. While the All-on-5 system provided better load distribution, the study highlights the importance of optimizing implant positioning based on mandibular anatomy. Despite limitations such as the use of static forces and standardized arch types, these findings offer valuable insights into the biomechanical performance of full-arch implant rehabilitations, supporting future clinical applications and research.

Authors: Sema Nur Sevinç Gül, Fahri Murat, Abdullah Tahir Şensoy
Publish Year: 2025
Oral and ocular manifestations in a patient with coronavirus disease-2019: Clinical presentation and management

Revista da Sociedade Brasileira de Medicina Tropical
Authors: Alparslan Dilsiz, Emine Parlak, Sema Nur Sevinç Gül
Publish Year: 2022
Effects of Ozone Threapy as an Adjunct to Non-Surgical Periodontal Treatment on Clinical Periodontal Parameters and Inflammatory Markers in Periodontitis Patients

Meandros Medical And Dental Journal

Objective: Ozone therapy (OT) is known to eliminate pathogens in the periodontal pocket and accelerate wound healing.This study aimed to investigate the clinical and biochemical efficacy of OT as adjunctive scaling and root planning (SRP) in the treatment of periodontitis. Materials and Methods:Fifty systemically healthy individuals with periodontitis were included in this study.Gingival crevicular fluid (GCF) samples were taken from the patients before and 8 weeks after starting the treatment, and gingival index (GI), plaque index (PI), bleeding on probing (BOP), pocket depth (PD), and clinical attachment level (CAL) were obtained from all subjects.Non-surgical periodontal treatment was applied to the test and control groups, and gaseous ozone treatment was applied in addition to the test group.TNF-α, IL-1β, IL-6, IL-10, and MMP-9 values in GCF samples before and after treatment were determined by the ELISA method and evaluated statistically.Results: Both groups presented significantly decreased clinical periodontal parameters at 8-week from baseline (p<0.05).Clinical periodontal parameters were found to be significantly lower in the test group than In the control group, there was a decrease in TNF-α levels after non-surgical periodontal treatment (p<0.05).Both groups demonstrated significantly decreased IL-1β, IL-6, IL-10, and MMP-9 levels at 8-week (p<0.05).The test group showed a significant decrease in MMP-9 levels compared with the control group at 8-week (p<0.05). Conclusion:As a result of the close relationship observed between clinical periodontal measurements and biochemical parameters, it was observed that clinical periodontal healing affects biochemical parameters, and in addition to non-surgical periodontal treatment, ozone treatment improves clinical periodontal measurements and affects biochemical parameters by reducing the GCF volume.

Authors: Sema Nur Sevinç Gül, Alparslan Dilsiz, Nurinnisa Öztürk, Mehmet Ali Gül
Publish Year: 2023
Güncel Periodontoloji Çalışmaları III

Gingival Ünite Greftinin Periodontal Plastik Cerrahide Kullanımı Ezgi GÜRBÜZ Zeki KAÇAR Damla Kan KARABIYIK Fatma KAVRUK Gerodontoloji ve Periodontal Durum Yasemin Beliz ÖNDER Dicle ALTINDAL Dental Mikrocerrahinin Gelişimi ve Periodontolojide Kullanımı Özlem SARAÇ ATAGÜN Periodontal Doku Mühendisliğinde Yeni Yaklaşımlar Eda ÇETİN ÖZDEMİR İmplant Tedavisi Açısından Canalis Sinuosusun Konik Işınlı Bilgisayarlı Tomografi ile Değerlendirilmesi Emrah BİLEN Hamide DURSUN ZAHİTOVİC Periodontitis ve Romatoid Artrit Başak BIYIKOĞLU Tümer TEKİN Dental İmplant Başarısızlığının Etiyolojisi ve Yönetimi Sema Nur Sevinç GÜL Ladise Ceylin HAS Endodontik Periodontal Lezyonlar Sema Nur SEVİNÇ GÜL Faezeh NADERLOU Dişeti Çekilmelerinde Güncel Tedavi Yaklaşımları Egemen TAYAN Periodontal Hastalıklar ve Covid-19 Arasındaki İlişki Egemen TAYAN Ceren GÖKMENOĞLU

Authors: Ezgi Gürbüz, Zeki Kaçar, Damla Kan Karabıyık, Fatma Kavruk, Yasemin Beliz Önder, Dicle Altındal, Özlem Saraç Atagün, Eda Çetın Özdemır, Emrah Bilen, Hamide Dursun Zahitovic, Başak Bıyıkoğlu, Tümer Tekin, Sema Nur Sevinç Gül, Ladise Ceylin Has, Faezeh Naderlou, Egemen Tavan, Ceren Gökmenoğlu
Publish Year: 2024
Eugenol alleviates the negative effects of experimental periodontitis and regulates adipokine hormones in rats

South African Journal of Botany
Authors: Sema Nur Sevinç Gül, Didem Özkal Emi̇noğlu, Emre Tekçe, Bülent Bayraktar, Leyla Güven, Alparslan Dilsiz, Serkan Yıldırım, Ahmet Sait
Publish Year: 2024
Güncel Periodontoloji Çalışmaları IV

Bağ Doku ve Bağ Doku Greftleri Sema Nur SEVİNÇ GÜL Ayşegül TÜRKSOY Alparslan DİLSİZ Çürüksüz Servikal Lezyonlarda Periodontal Tedavi Yaklaşımları Ezgi GÜRBÜZ Beyza TETİK Diyabet Periodontitis İlişkisi ve Güncel Tedavi Yaklaşımları Bilkan KARA Peri-İmplant Yumuşak Doku Yönetiminde Komplikasyonlar Zeynep Hazan YILDIZ Gülbahar USTAOĞLU Seval CEYLAN ŞEN Periodontal Hastalığı Olan Bireylerde Ortodontik Tedaviler Özlem SARAÇ ATAGÜN Periodontal Rejenerasyon ve Rejeneratif Teknikler Gülbahar USTAOĞLU Seval CEYLAN ŞEN Periodontolojide Trombositten Zengin Fibrin Kullanım Alanları Zeynep Hazan YILDIZ Gülbahar USTAOĞLU Diş Hekimliğinde Probiyotik Kullanımı Kevser SÖKMEN Bilge KARCI Sinem EKİZ Periodontolojide Lazer Uygulamaları Bilge KARCI Kevser SÖKMEN Pınar GÜLTEKİN

Authors: Sema Nur Sevinç Gül, Ayşegül Türksoy, Alparslan Dilsiz, Ezgi Gürbüz, Beyza Tetik, Bilkan Kara, Zeynep Hazan Yıldız, Gülbahar Ustaoğlu, Seval Ceylan Şen, Özlem Saraç Atagün, Kevser Sökmen, Bilge Karcı, Sinem Ekiz, Pınar Gültekin
Publish Year: 2025
Güncel Periodontoloji Çalışmaları V (Bahar)

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Authors: Kübra Eskin, Mehmet Güzel, Hacer Sahin, Müzeyyen Kandemir, Ebru Sarıbaş, Mustafa Özay Uslu, Pınar Gültekin, Ayşe Şen, Gökhan Özgenç, Sema Nur Sevinç Gül, Tuğçe Dönmezer, Mehmet Ali Günenç, Osman Fatih Arpağ, Ayşegül Sarı, Ziynet Gül Gürses, Gurbet Alev Öztaş Şahiner, Güler Başyiğit
Publish Year: 2025
Predictive mathematical modeling of biomechanical behavior in all-on-4 implants design: effects of distal implant and occlusal load angulation using RSM based on FEA

Frontiers in Bioengineering and Biotechnology

This study presents a predictive biomechanical modeling approach for optimizing distal implant placement in the All-on-4 treatment concept, with a focus on implant angulation and occlusal load direction. Finite Element Analysis (FEA) was integrated with Response Surface Methodology (RSM) to develop 15 simulation models based on a Central Composite Design, incorporating distal implant angulations of 15°, 30°, and 45°, and occlusal load directions in both sagittal and frontal planes (45°, 67.5°, and 90°). The maximum von Mises stress in cortical bone was selected as the response variable. Regression analysis revealed that the frontal load angle had the most significant effect on stress distribution, followed by implant angulation. The resulting second-order predictive model demonstrated a strong statistical fit (R<sup>2</sup> = 93.39%, adjusted R<sup>2</sup> = 81.49%). The lowest cortical stress (95.75 MPa) occurred at 15° implant angulation with 45° occlusal loading in both planes, whereas the highest stress (265.72 MPa) was recorded at 45° angulation with 90° frontal loading. Although reducing implant tilt generally decreases peri-implant stress, no universally optimal angle can be defined due to variability in biomechanical responses under different occlusal loading conditions. Clinically, optimizing cusp inclination and load direction in conjunction with implant positioning may enhance the biomechanical performance and long-term success of full-arch implant-supported prostheses.

Authors: Fahri Murat, Sema Nur Sevinç Gül, Abdullah Tahir Şensoy
Publish Year: 2025
CF-PEEK vs. Titanium Dental Implants: Stress Distribution and Fatigue Performance in Variable Bone Qualities

Biomimetics

This study aims to evaluate the biomechanical behavior of titanium and carbon fiber-reinforced polyetheretherketone (CF-PEEK) dental implants under varying bone densities and loading conditions using finite element analysis (FEA). A single-tooth mandibular molar implant system was modeled, comprising titanium or CF-PEEK abutment and fixture, and surrounding bone structures with four configurations: (I) fully cortical bone, (II) 2 mm cortical layer with trabecular bone, (III) 1 mm cortical with high-density trabecular bone, and (IV) 1 mm cortical with low-density trabecular bone. Vertical and oblique static loads of 100 N were applied to simulate masticatory forces. FEA results revealed that titanium implants exhibited higher von Mises stress values in the implant and abutment under oblique loading, exceeding 400 MPa, while CF-PEEK components showed reduced stress but significantly higher strain levels. Cortical and trabecular bone surrounding CF-PEEK implants received more uniform stress distribution, potentially minimizing stress shielding effects. However, fatigue life analyses indicated that CF-PEEK abutment and screw components were more susceptible to mechanical failure under oblique loads, particularly in low-density bone models. In conclusion, CF-PEEK implants offer a more physiological load transfer to bone and reduced stress shielding compared to titanium. However, their structural reliability under complex loading, especially in low-quality bone conditions, requires careful consideration. These findings support the potential use of CF-PEEK in select clinical scenarios but highlight the need for further material and design optimization.

Authors: Nurdan Polat Sağsöz, Fahri Murat, Sema Nur Sevinç Gül, Abdullah Tahir Şensoy, İrfan Kaymaz
Publish Year: 2025
Medical Emergency Management in Dental Clinics: A Cross-Sectional Assessment of Knowledge, Attitudes, and Practices

Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi

Objective: This study aimed to assess dentists’ knowledge, attitudes, practices, and self-confidence regarding medical emergencies, as well as to determine the frequency, types, and severity of such events encountered in dental settings. Additionally, the availability of essential emergency equipment and drugs, dentists’ preparedness levels, and prior training experiences were evaluated. Methods: A cross-sectional survey was conducted among 120 dentists using a previously validated and reliable questionnaire. The survey assessed demographic characteristics, clinical experience, prior encounters with medical emergencies, availability of equipment, and perceived self-efficacy. Frequency analyses and association tests were employed to examine the relationships between encountering medical emergencies, training background, and equipment availability. Results: Within the past 12 months, hypoglycemia (32.5%) emerged as the most frequently reported emergency, surpassing vasovagal syncope (25.8%), which is commonly emphasized in the literature. Dentists who reported serious medical emergencies also indicated higher levels of equipment availability and prior exposure to minor emergencies. Among those who had witnessed cardiac arrest, the majority (80%) had not received postgraduate training, and none (100%) had used a defibrillator. Oxygen use (27.5%) showed a strong association with prior training during undergraduate education. Conclusion: The findings highlight significant variability in emergency preparedness among dentists. Continuous, hands-on training and standardized emergency protocols are crucial for enhancing clinical competence and improving patient safety in dental practice

Authors: Sema Nur Sevinç Gül, Alparslan Dilsiz, Edanur Diri, Ismayıl Huseynlı
Publish Year: 2025
Oral Health Status and Salivary Elemental Composition in Pregnancy: A Quantitative ICP-MS Study

Turkiye Klinikleri Journal of Dental Sciences

Objective: Pregnancy is associated with profound physiological and hormonal changes that significantly influence oral health, including both qualitative and quantitative alterations in the composition of oral fluids. The objective of this study is to investigate the relationship between salivary macro- and trace element levels and oral hygiene status during pregnancy. Material and Methods: A total of 100 participants were categorized into 4 groups: non-pregnant women with healthy periodontium, non-pregnant women with gingivitis, pregnant women with healthy periodontium, and pregnant women with gingivitis. Saliva samples were analyzed using inductively coupled plasma mass spectrometry to determine concentrations of Sodium (Na), potassium (K), magnesium (Mg), calcium, iron, zinc (Zn), copper, selenium (Se), cobalt, chromium, and manganese. Clinical periodontal parameters-plaque index (PI), gingival index (GI), bleeding on probing (BOP), clinical attachment level (CAL), probing depth (PD)-and the Decayed, Missed, Filled Teeth Index were also recorded. Results: PI, GI, BOP, CAL, and PD were significantly higher in pregnant women with gingivitis compared to other groups (p<0.001). Na, K, and Mg levels were significantly elevated in pregnant women with gingivitis, while Zn was lowest in non-pregnant women with gingivitis (p<0.01 or p<0.05). Se levels were significantly increased in the pregnant group (p<0.01). Conclusion: These findings suggest that pregnancy and periodontal health status are associated with alterations in salivary element composition, emphasizing the potential impact of gingival inflammation on oral biochemical profiles during pregnancy.

Authors: Sema Nur Sevinç Gül, Alparslan Dilsiz, E. Laloğlu, Gamze Nur CİMİLLİ ŞENOCAK
Publish Year: 2026
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