Dr. Sakarie Mustafe Hidig is a General Surgeon affiliated with the Fourth Affiliated Hospital of Zhejiang University School of Medicine. He also serves as Editor-in-Chief at the Research Center, Hargeisa Group Hospital, and is the UK Country Coordinator for the International Institute of Knowledge Management (TIIKM).He is a member of the China Medical Association (CMA), Somali Medical Association (SMA), and the Scholars Academic and Scientific Society (SAS), where he holds a Young Research Fellow Membership (SYRFM). Dr. Hidig has been recognised with multiple international awards, including SHEN (2022, 2023, 2025), GCDMSE (2024), and the ISSN Research Award (2024). In addition to his clinical and academic roles, Dr. Hidig serves as an editor for several international journals, including PLOS One Medicine, Annals of Medicine and Surgery, Obesity Surgery, Aegean Journal of Medical Science, Frontiers, and the JMIR Journal of Public Health and Surveillance. He has authored or co-authored over 75 international publications and has handled more than 200 SCI-indexed papers as an editor.
His research interests span general surgery gastrointestinal surgery trauma and emergency surgery hepatobiliary and pancreatic surgery as well as public health.
Abstract Background The purpose of this study was to measure the femoral prosthesis flexion angle (FPFA) in total knee arthroplasty (TKA) using three-dimensional reconstruction, and to assess the differences in early clinical efficacy between patients with different degrees of flexion. Methods We conducted a prospective cohort study. From June 2019 to May 2021, 113 patients admitted for TKA due to osteoarthritis of the knee were selected. The patients’ postoperative knee joints were reconstructed in three dimensions according to postoperative three-dimensional computed tomography (CT) scans. The FPFA was measured, and the patients were divided into 4 groups: anterior extension group (FPFA < 0°), mildly flexed group (0° ≤ FPFA < 3°), moderately flexed group (3° ≤ FPFA < 6°) and excessively flexed group (6° ≤ FPFA). The differences in the Knee Society Score (KSS), knee Range of Motion (ROM), and visual analogue scale (VAS) scores were measured and compared between the four groups at each postoperative time point. Results Postoperative KSS, ROM, and VAS were significantly improved in all groups compared to the preoperative period. At 1 year postoperatively, the ROM was significantly greater in the mildly flexed group (123.46 ± 6.51°) than in the anterior extension group (116.93 ± 8.05°) and the excessively flexed group (118.76 ± 8.20°) ( P < 0.05). The KSS was significantly higher in the mildly flexed group (162.68 ± 12.79) than in the other groups at 6 months postoperatively ( P < 0.05). The higher KSS (174.17 ± 11.84) in the mildly flexed group was maintained until 1 year postoperatively, with a statistically significant difference ( P < 0.05). No significant difference in VAS scores was observed between groups at each time point. Conclusions A femoral prosthesis flexion angle of 0–3° significantly improved postoperative knee mobility, and patients could obtain better Knee Society Scores after surgery, which facilitated the postoperative recovery of knee function. Trial registration ChiCTR2100051502, 2021/09/24.
BACKGROUND: The main objective of this study was to predict the status of blood and the occurrence of lower limb deep vein thrombosis (DVT) after total knee arthroplasty(TKA) by means of mean platelet volume (MPV) combined with thromboelastography (TEG). METHODS: We collected 180 patients who underwent unilateral total knee arthroplasty between May 2015 and March 2022, and the patients were divided into DVT group and control group according to whole-leg ultrasonography on the seventh postoperative day. Blood count and TEG were performed on the day before surgery, the first day after surgery and the seventh day respectively. Multifactorial analysis was used to investigate whether the relevant parameters were independent predictors of DVT after TKA. RESULTS: MPV has the strongest correlation with the maximum amplitude (MA), followed by alpha-angle; MPV and alpha-angle on the first postoperative day are independent predictors of DVT. MPV in patients with thrombosis tends to rise and then fall in the perioperative period. The optimal threshold for MPV to predict thrombosis is 10.85 fL and the area under the ROC curve is 0.694, The area under the ROC curve increases to 0.815 using MPV combined with alpha-angle. In addition, MA, α-angle, composite coagulation index (CI) and MPV were all statistically higher in the DVT group than in the control group (p < 0.001). CONCLUSION: MPV is a predictor of DVT after TKA. It can reflect the hypercoagulable state of blood after surgery; Combination of MPV and alpha-angle on the first day after surgery in patients with TKA improves predictive power of DVT.
Somalia, a country located in the Horn of Africa, has long grappled with significant healthcare challenges exacerbated by decades of conflict, instability, and underdevelopment. In 2024, despite ongoing efforts to rebuild its healthcare system, Somalia continues to face multifaceted healthcare issues that hinder the delivery of essential services to its population. This report aims to provide an in-depth analysis of the current state of healthcare in Somalia, focusing on challenges, recent advancements, and potential solutions. Somalia’s healthcare system is characterized by a fragile infrastructure, inadequate resources, and a shortage of skilled healthcare professionals. The country’s healthcare services are predominantly provided by non-governmental organizations (NGOs) and international agencies, with limited government capacity to deliver healthcare at the national level. Access to healthcare remains a significant challenge in Somalia, particularly in rural and conflict-affected areas. Factors such as geographic barriers, insecurity, and financial constraints impede individuals’ ability to seek and receive healthcare services.1 Somalia’s healthcare infrastructure is severely underdeveloped, with many healthcare facilities lacking essential resources such as medical equipment, medications, and trained personnel. The quality of healthcare services varies widely across regions, with urban areas generally having better-equipped facilities compared to rural areas. Infectious diseases such as malaria, cholera, and measles continue to pose significant public health threats in Somalia. Weak disease surveillance systems, inadequate access to clean water and sanitation facilities, and population displacement contribute to the spread of communicable diseases.2Somalia’s maternal and child health indicators are among the poorest globally, with high maternal and child mortality rates attributed to limited healthcare access, and cultural and socio-economic factors. Recent years have seen the emergence of telemedicine and mobile health initiatives in Somalia, leveraging technology to improve access to healthcare services, particularly in remote and underserved areas. Mobile health applications and teleconsultation services enable individuals to receive medical advice and consultations remotely, overcoming barriers to access. International partnerships and humanitarian assistance play a vital role in supporting healthcare delivery in Somalia. Organizations such as the World Health Organization (WHO), UNICEF, and Médecins Sans Frontières (MSF) provide essentialmedical supplies, healthcare training, and support for healthcare facilities in the country. Community-based healthcare initiatives, including community health workers and outreach programs, are instrumental in delivering healthcare services at the grassroots level.3These initiatives focus on health education, disease prevention, and maternal and child health, addressing healthcare needs within local communities. Investments in healthcare infrastructure, training, and capacity building are crucial for improving healthcare delivery in Somalia, including upgrading facilities, providing resources, and expanding coverage to underserved areas. Training programs in Somalia should enhance clinical skills, promote evidence-based practices, and strengthen healthcare management while empowering communities through health education, mobilization, and participatory decision-making processes. Engaging communities in healthcare planning and implementation ensures that interventions are culturally appropriate and responsive to local needs. Enhancing disease surveillance systems and improving outbreak response capacity are crucial for controlling infectious diseases in Somalia. This includes strengthening laboratory capacity, training healthcare workers in disease surveillance and reporting, and enhancing coordination among healthcare stakeholders. The healthcare challenges facing Somalia are complex and multifaceted, requiring coordinated efforts from the government, civil society, and the international community to address them effectively. By prioritizing investments in healthcare infrastructure, strengthening healthcare systems, and empowering communities, Somalia can make significant strides toward improving healthcare access and outcomes for its population.
In the last few years, the incidence of telangiectasia and small bleeding complicated with chronic myelomonocytic leukemia (CMML) in patients treated for small bowel bleeding has been increasing, yet to the best of our knowledge, we describe this rare case of telangiectasia and small bowel bleeding with CMML.Telangiectasia, also known as spider veins, is a disorder causing abnormal capillary diameter dilation, microvascular wall fragility, and increased blood drainage.1 It has a low incidence but a high case fatality rate. Small bowel bleeding due to capillary dilation is a threatening condition with a high case fatality rate. Chronic mononucleosis (CMML) is a rare, variable disease primarily seen in elderly patients, characterized by leukemic dysplasia, hematopoiesis, and monocyte proliferation, with an average survival time of 12–18 months.Case 1: A 76-year-old male experienced intermittent melena for 15 days, which worsened for 2 days. After a polypectomy, he complained of black stool for 2 days, followed by dizziness, fatigue, palpitation, and discomfort. He underwent blood transfusions, hemostasis, and other treatments. A colonoscopy revealed multiple ulcers in the small intestine and mucosal bulges[Fig1]. Intraoperative surgical exploration revealed fine capillaries in the ileal intestinal wall. Partial ileal resection was performed, and the patient’s white blood cells increased to 37 x 109/L, hemoglobin increased to 82 x 109/L, and platelets decreased to 99 x 109/L. the patient with CMML, diagnosed with a genetic mutation in the ASXL gene, had high white blood cell variability, high blood pressure, and a severe lung infection. He died one year after surgery but improved after iron polysaccharide and thalidomide treatment.The patient with a small bowel bleeding disorder (SBB) showed increased blood levels after hospital discharge. Treatments included blood transfusions, fluid replacement, acid suppression, and hemostasis. However, telangiectasia persisted. Despite advances, some patients remain undetected due to a lack of symptoms. The patient refused a bone marrow aspiration which was confirmed through genetic testing.Gene mutations in TET2, SRSF2, and ASXL1 are significant diagnostic and prognostic factors in CMML patients. Clinical manifestations are insidious, and laboratory features are ambiguous, making them easy to miss and misdiagnose. In one patient, a delay in diagnosis may be due to a misinterpretation of leukocytosis due to bone marrow compensatory capacity or temporary narrowing of the spleen. The patient’s mucosal injury may cause small bowel bleeding due to white blood cell infiltration into the vascular wall.2Small bowel bleeding with CMML has low mortality rates, but physicians should differentiate it from other hematological diseases to avoid confusion and misdiagnosis, especially when dealing with difficult-to-control hematomas or anemias.
In low-income healthcare settings, the implementation of informed consent faces significant challenges despite its pivotal role in upholding patient autonomy and dignity. A study conducted in southeastern Nigeria at the University of Nigeria Teaching Hospital sheds light on these challenges, particularly concerning patient satisfaction and recall of critical information post-consent. While many patients recalled details about their medical condition and planned procedures, there was notably lower recall of associated risks, emphasizing the complexity of conveying risk-related information effectively. Importantly, the study reveals a correlation between patient satisfaction with the consent process and their subsequent recall of information, underlining the intrinsic link between patient engagement, satisfaction, and comprehension. To bridge this gap, tailored communication methods and addressing patient concerns are essential. Systemic deficiencies in the consent process, including generic forms and linguistic barriers, call for interventions such as culturally sensitive consent materials and capacity building for healthcare providers. Looking forward, innovative approaches, including pictorial aids and mobile health applications, should be explored, alongside longitudinal studies to assess their impact. Ultimately, prioritizing patient satisfaction and comprehension in the consent process is crucial for upholding ethical standards in healthcare delivery, even amidst resource constraints.
Objective: To compare the clinical effects of Amiodarone and Propafenone in the treatment of arrhythmia. Methods: Choose our hospital 100 cases of patients with cardiac arrhythmias. We shall divided into control group (50 cases, Propafenone treatment) and treatment group (50 cases, Amiodarone therapy), to collect the curative effect of two groups of patients, adverse reactions, nausea and vomiting, dizziness, headache, low blood pressure, heart rate slow down) in accordance with the drug treatment and electrocardiogram (ecg) changes before and after the treatment (PR interphase, QT interphase, QRS duration). Results: Control group and the clinical curative effect of treatment group total effectiveness 98%, 86% respectively, the treatment group is significantly higher than the control group. Control group and treatment group the incidence of adverse reactions were 4%, 12%, treatment group was significantly lower than the control group, and two groups of patients duration are improved after treatmentstage PRinterval and QT, QRS.But the treatment group patients with stage PRinterval and QT,such as electrocardiogram QRS duration change was better than control group, which difference hasstatisticalsignificance (P &lt; 0.05). Conclusion: Compared with propafenone, amiodarone in the treatment of arrhythmia patients has better therapeutic effect and higher safety, and improve the clinical symptoms of patients effectively. It is suggested to promote clinical practice.
Objective: To analyze the clinical effect and complication rate of emergency surgery for severe chest trauma with traumatic shock. Method: A total of 100 patients with severe chest trauma and traumatic shock admitted to our hospital from November 2017 to November 2018 were randomly selected. All the patients were divided into the reference group (50 cases, elective surgical treatment) and the study group (50 cases, emergency surgical treatment) according to the difference in surgical treatment time. At the same time, the effect of surgical treatment, incidence of complications (organ failure, respiratory distress syndrome, empyema, pulmonary infection) and clinical indicators (recovery time of respiratory function, mortality) of patients in the two groups were compared and analyzed. Consequence: The total effective rate of clinical efficacy in the control group and the treatment group was 98% and 86%, so treatment group was significantly higher than the control group. The incidence of adverse reactions in the control group and the treatment group was 4% and 12%, so treatment group was significantly lower than the control group, and the recovery time and mortality of respiratory function in the treatment group were lower than those in the control group, with significant differences in all comparisons (P &lt; 0.05). Conclusion: Emergency surgery for patients with severe chest trauma and traumatic shock has a significant therapeutic effect, which can effectively reduce the risk of postoperative complications, improve the prognosis of patients and reduce the short-term mortality of patients.
Objective: Gastric cancer (GC) is one of the most important upper gastrointestinal malignancies worldwide.Anti-tumor effect of PD-1/PD-L1 inhibitor alone is insufficient, furthermore its combination chemotherapy provides a new direction.To analyze the effectiveness and safety of combination therapy of PD-1/PD-L1 inhibitor combined with CHEMO in regimens of advanced gastric carcinoma (GC).Chinese and English databases were searched to collect clinical randomized controlled trials (RCTs) of PD-1/PD-L1 inhibitors combined with CHEMO in therapy of advanced carcinoma GC/ gastroesophageal junction cancer (GEJC).Combined group ORR (OR=2.63,95%CI: 1.47~4.68)and DCR (OR=2.42,95%CI: 1.07~5.51)higher than the control group, FPS (HR=0.71,95%CI: 0.65~0.77)and OS (HR=0.80,95%CI: 0.73~0.86)showed a significantly better condition than control group.The occurrence rate of grade 3-5 untoward effects in the combination group showed a higher data than control group, OR=1.24 (95CI: 1.03, 1.49).PD-1/PD-L1 inhibitor combined with CHEMO can promote the treatment effect in advanced GC and build up the medical forecast of patients, but it can increase the incidence of serious adverse reactions.
Background: This study aims to better understand diagnosing and treating arterial gastrointestinal fistulas. Methods: The diagnosis and treatment of two patients with arterial gastrointestinal fistulas were reported, and the experience with diagnosis and treatment was summarized. Results: In these two cases, both patients were admitted with bleeding as the primary complaint, both underwent emergency laparotomies, and both patients were diagnosed with small intestinal bleeding before surgery. the first patient died as a result of an abdominal aortic aneurysm rupture caused by chronic vascular repair and postoperative implant infection; the second patient underwent vascular repair on time, we treated him with third-generation cephalosporin, and after he was stabilized, we performed left total iliac stent placement and left internal iliac artery embolization; he had no fever after surgery, his incision was healed, and he was successfully discharged from the hospital. Conclusion: Aortic gastrointestinal fistula is rare and has a high mortality rate, attention should be paid to distinguishing it from small intestinal bleeding. Timely diagnosis and rapid surgical treatment are keys to improving survival.
To discuss and analyze the diagnosis and treatment methods of small bowel diverticulum to improve the level of diagnosis and treatment. The clinical data of two patients with small bowel diverticulum found by intraoperative exploration in our hospital were analyzed, and the preoperative and postoperative diagnoses were compared, as well as the causes and treatment methods of misdiagnosis. The two patients could not be clearly diagnosed before surgery, but they were clearly diagnosed during surgical exploration, and they were discharged after surgical treatment. Small intestinal diverticulum has no specific clinical manifestations; preoperatively, it is not easy to diagnose and is often diagnosed in autopsies or other operations. Patients with acute abdomen and gastrointestinal bleeding, such as small intestinal bleeding and acute appendicitis, should be vigilant for small bowel diverticula to avoid delaying the condition and causing serious consequences.
In the clinic, valgus knees are relatively infrequent. To achieve a balance between the soft tissue and bone and prevent nerve injury, treatments for valgus deviations >20° provide a surgical challenge. The implications of lower-limb valgus deformity greater than 20°, a unique condition, have not been thoroughly examined in many articles. We described a 66-year-old woman who had a severe, permanent valgus deformity in her right knee. The patient's right knee had a preoperative range of motion (ROM) of 30-95° of flexion and a 25° permanent valgus deformity.
To discuss and analyze the diagnosis and treatment methods of small bowel diverticulum to improve the level of diagnosis and treatment. Methods: The clinical data of two patients with small bowel diverticulum found by intraoperative exploration in our hospital were analyzed, and the preoperative and postoperative diagnoses were compared, as well as the causes and treatment methods of misdiagnosis. Results: The two patients could not be clearly diagnosed before surgery, but they were clearly diagnosed during surgical exploration, and they were discharged after surgical treatment. Conclusion: Small intestinal diverticulum has no specific clinical manifestations; preoperatively, it is not easy to diagnose and is often diagnosed in autopsies or other operations. Patients with acute abdomen and gastrointestinal bleeding, such as small intestinal bleeding and acute appendicitis, should be vigilant for small bowel diverticula to avoid delaying the condition and causing serious consequences.
COVID-19 is a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that began in Wuhan, China, in late 2019 and has since spread globally, disrupting efforts to contain it. In Africa, the COVID-19 infection may be influenced by malaria coinfection. Global health is severely hampered by the co-infection of COVID-19 and malaria, especially in areas where both illnesses are endemic. Studies that have already been conducted indicate that those who have co-infection may have more severe symptoms and a higher risk of dying, even though there is little information on the prevalence and consequences of co-infection. More studies and focused initiatives are required to address this issue because of the difficulties in diagnosing the two diseases and the possibility that co-infection would worsen already existing health inequities. Methodology: This review follows the guidelines of PRISMA. In this article, we reviewed published articles from 2019 to May 2023 on COVID-19 and malaria co-infection that might influence the ontology of COVID-19. Results: Sub-Saharan African countries have fewer COVID-19 cases due to factors like young populations, warm weather, lack of proper diagnosis, malaria history, and antimalarial drug use. Population genetics also influence COVID-19 dynamics. Clinical and pathological similarities between malaria and COVID-19 have confused diagnosis and treatment in Africa. Conclusion: Understanding the dynamics of COVID-19 infection in Sub-Saharan Africa and how another endemic disease like malaria shapes it can provide insights into how to tailor successful diagnostic, intervention, and control plans that lower disease morbidity and mortality. Coinfection with COVID-19 and malaria is related to expanded all-cause in-hospital mortality compared to mono-infection with serious acute respiratory disorder coronavirus 2 (SARS-CoV-2).
Abstract Background: According to growing evidence, high-density lipoproteins (HDLs ) may raise PSA levels in the prostate. The link between HDL-C and PSA, on the other hand, is debatable and challenging. Hence, this research examined the relationship between HDL-C and PSA in men using the National Health and Nutrition Examination Survey (NHANES) database. Methods: We extracted NHANES data for five cycles from 2001 to 2010. The data used for analysis included PSA concentrations, sociodemographic data, and laboratory data. After the screening, 6,669 of 52,195 participants were included in the study. Participants were divided into 4 groups based on HDL-C quartiles. We analyzed categorical and continuous variables using weighted chi-square tests and linear regression models to compare differences between groups. We constructed 3 weighted multivariate linear regression models and assessed the association between HDL-C and PSA using a smoothed curve fit. Results: In our study, unadjusted and adjusted multivariate linear regression models revealed a significant positive association between prostate-specific antigen (PSA) concentrations and serum high-density lipoprotein cholesterol (HDL-C) levels. Specifically, each unit increase in HDL-C ratio was associated with an increase in PSA concentration by 0.470 ng/mL (P < 0.001) in the unadjusted model. In minimally adjusted models, accounting for socioeconomic and demographic factors, this correlation remained significant, with an increase of 0.408 ng/mL per unit increase in serum HDL-C (P < 0.001). Furthermore, the stratified analysis revealed various impacts based on socioeconomic status and HDL-C levels, with a significant interaction between household income and HDL-C levels (P = 0.037). Exclusion of subjects with low HDL-C levels strengthened the association, showing a significant increase in PSA concentration with higher HDL-C levels (0.50 ng/mL per 1 mmol/L increase, P = 0.009). Our findings suggest a nuanced relationship between HDL-C levels, socioeconomic factors, and PSA concentrations, highlighting the potential importance of considering these factors in prostate cancer screening and risk assessment. Conclusion: This study found a positive association between serum HDL-C and PSA concentrations in adult men in the United States without a prostate cancer diagnosis. Moreover, People with low HDL-C are more likely to be diagnosed with prostate cancer in the late stage of the disease. Hence, people with high levels of HDL-C should be tested for PSA to help early detection of prostate cancer.
Ovarian cancer is the deadliest and most common gynecological cancer, with a significant incidence and variety worldwide.It ranks eighth among the leading causes of cancer mortality, with 151900 deaths, and seventh among the leading cancer diagnoses among women, with 238700 new cases worldwide.The objective of this study is to identify the characteristics of ovarian cancer.The prognosis and clinical management of ovarian cancer depend on the cancer's stage.Approximately sixty percent of ovarian cancer patients have a metastatic illness by the time they are diagnosed; the early stages of the disease are often asymptomatic.The analysis involved three hundred clinical cases of ovarian cancer collected at the third affiliated hospital of Xinjiang Medical University in China.The analytical process entailed using the Statistical Package for the Social Sciences (SPSS) due to the large dataset.The study found that patients aged between forty and fifty-nine are the most vulnerable to ovarian cancer incidence.Malignant ovarian tumors (moderately differentiated adenocarcinoma) had the highest prevalence within the provided sample.
Ovarian cancer is the deadliest and most common gynecological cancer, with a significant incidence and variety worldwide.It ranks eighth among the leading causes of cancer mortality, with 151900 deaths, and seventh among the leading cancer diagnoses among women, with 238700 new cases worldwide.The objective of this study is to identify the characteristics of ovarian cancer.The prognosis and clinical management of ovarian cancer depend on the cancer's stage.Approximately sixty percent of ovarian cancer patients have a metastatic illness by the time they are diagnosed; the early stages of the disease are often asymptomatic.The analysis involved three hundred clinical cases of ovarian cancer collected at the third affiliated hospital of Xinjiang Medical University in China.The analytical process entailed using the Statistical Package for the Social Sciences (SPSS) due to the large dataset.The study found that patients aged between forty and fifty-nine are the most vulnerable to ovarian cancer incidence.Malignant ovarian tumors (moderately differentiated adenocarcinoma) had the highest prevalence within the provided sample.
Dear Editor, I would like to share my opinions on the article “Exploring Perspectives on Cancer Screening in People Aged 30-70: A Comparative Study of Those with and Without Type 2 Diabetes,” published in the Konuralp Medical Journal (2024;16(1):26-31). First and foremost, I commend the authors for their significant contributions to the field, addressing a topic of critical importance to physicians engaged in cancer research. This study, which investigates attitudes and behaviors towards cancer screening in individuals with and without type 2 diabetes mellitus (T2DM), is particularly notable for its potential public health implications given the increased cancer risk associated with diabetes (1).
Most patients undergoing orthopedic surgeries experience moderate to acute pain. Initially, opioids were the main medication that targeted mechanisms of pain transmission. However, the use of opioids has a lot of risks, including addiction, respiratory depression, urinary retention, vomiting, and nausea. Over the years, multimodal analgesia has become the preferred pain control or management strategy in orthopedic practice. Administering more than one mode to address postoperative pain by recruiting several receptors via various medications decreases the need for opioids and speeds up the recovery process. Implementation of effective analgesic interventions and strategies reduces preoperative opioid intake, subsequently preventing addiction to pain drugs and the risk of opioid overdose. Multimodal analgesia has been a crucial component of pain management in orthopedic surgery since early opioid consumption. This essay explores the concept of multimodal analgesia as a pain management mechanism in orthopedic surgery. It provides an overview of the elements of multimodal analgesia and also highlights the opioids.
Letter to Editor: Unraveling the Complexity of Spleen Evaluation: A Critical Analysis of Ultrasonography Studies
Dear Editor, I would like to share my professional opinion on the case report authored by Emre Berat Akçay, Kadir Çorbacı, and Ali Sürmelioğlu (1), published in the Journal of Izmir Faculty of Medicine, 2024; 3(1): 61-65. Firstly, I want to thank the authors for their valuable contribution to the field. Their case report presents two instances of paraduodenal hernias (PDH), highlighting the challenges in diagnosing and managing this rare condition. The report underscores the importance of maintaining a high level of clinical suspicion, especially in patients with recurrent hospitalizations for unexplained abdominal pain or signs of intestinal obstruction.
Dear Editor, I would like to share my opinion on the article titled "Survival-effective Prognostic Factors of Rectal Cancer Patients Receiving Neoadjuvant Chemoradiotherapy," published in the Cerasus Medical Journal, Volume 1, Issue 2, pages 117-123, on June 14, 2024. The article was authored by Orhun Uzun et al [1]. Firstly, I want to thank the authors for their contribution to the field. The study's objective was clear: to identify survival-effective prognostic factors in this patient population. As mentioned by the researchers, they utilized a retrospective review of 102 patients who underwent surgery for rectal cancer at a single institution, ultimately including 84 patients in the analysis after applying exclusion criteria. While the study’s objective is well-defined, its design and scope present certain limitations that affect the strength and applicability of its conclusions.
Non-alcoholic fatty liver disease (NAFLD) has emerged as a significant public health concern, paralleling the global rise in obesity rates.
This comprehensive literature review is to summarize the most recent findings regarding the causes, diagnosis, and treatments of pancreatic cancer and to encourage additional investigation into this under-researched malignant tumor. Pancreatic cancer is a significant public health issue in China, with annual mortality rates almost equal to incidence rates. The disease is more prevalent in rural areas and has a poor prognosis. The data was collected from the following databases: PubMed, Crossref, Science Direct, Scopus, and Google Scholar we reviewed published articles from 2018 to 2023 on the annual incidence of pancreatic cancer in China is 5.1%, with only 5-7% of patients completely cured. The prognosis is extremely poor, with a 1-year survival rate of 8% and a 5-year survival rate of 3%. Pancreatic cancer has no specific clinical manifestations or tumor markers, and its characteristics are not typical of high-risk factors including smoking, alcohol, chronic pancreatitis, abnormal microorganism metabolism, blood type, and glucose and lipid levels. For increased detection and survival rates, pancreatic cancer must be diagnosed as early as possible. However, the low specificity of tumor markers calls for more study. Future treatment strategies could include immunotherapy and a microbiology-free system, and it's anticipated that they'll offer intriguing clinical applications for extending patients' lives with pancreatic cancer. Finally, we suggest measures to improve the health outcomes of pancreatic cancer patients in China.
In the bustling corridors of hospitals and the serene confines of clinics, healthcare professionals stand as pillars of strength and compassion, dedicated to healing others. Yet, behind the façade of white coats and stethoscopes lies a silent crisis that demands urgent attention the alarming prevalence of suicide among healthcare workers.
Objective: This study examines the use of CP in Somaliland schools and the psychological and behavioral impact of this practice on students as well as the impact of the practice on the performance of the student. Methods: This study used a qualitative study design in which a structured questionnaire was used to collect the necessary data regarding the study subject matter, and the data were analyzed via SPSS version 20 (IBM SPSS Corp., Armonk, NY, USA) Results: This study revealed a shocking prevalence of corporal punishment among Somaliland students. The study also demonstrated a strong link and statistical significance between corporal punishment and the psychological state of the students, as well as a positive relationship between corporal punishment and the behavior of the student. However, regarding the performance of the student, the study failed to find a reasonable statistical significance between this parameter and corporal punishment. Conclusion: There is a strong correlation between corporal punishment and the adverse psychological effects discussed in this study. The study also revealed a strong relationship between corporal punishment and the possible behavior issues of the pupils. The study highlighted a drawback of corporal punishment and a shift to alternatives among schools in Somaliland. Such alternatives may include positive reinforcement, rewarding good behavior, guidance and counseling, involving parents, time-outs, detentions, suspensions, motivations, recognition and praise tactics, revoking or taking away privileges, use of assignments and additional tasks such as punishment, and many other known methods as alternatives to corporal punishment.
According to increasing evidence, high-density lipoproteins (HDLs) may raise prostate-specific antigen (PSA) levels in the prostate. The link between HDL-cholesterol (C) and PSA, on the other hand, is debatable and challenging. Hence, the present study examined the relationship between HDL-C and PSA in men using the National Health and Nutrition Examination Survey (NHANES) database. NHANES data were extracted for five cycles from 2001 to 2010. The data used for analysis included PSA concentrations, sociodemographic and laboratory data. After the screening, 6,669 out of 52,195 participants were included in the present study. Participants were divided into four groups based on HDL-C quartiles. Categorical and continuous variables using weighted chi-square tests and linear regression models were analysed to compare differences between groups. A total of three weighted multivariate linear regression models were constructed and the association between HDL-C and PSA using a smoothed curve fit was assessed. In the present study, unadjusted and adjusted multivariate linear regression models revealed a significant positive association between PSA concentrations and serum HDL-C levels. Specifically, each unit increase in HDL-C ratio was associated with an increase in PSA concentration by 0.470 ng/ml (P<0.001) in the unadjusted model. In minimally adjusted models, accounting for socioeconomic and demographic factors, this association remained significant, with an increase of 0.408 ng/ml per unit increase in serum HDL-C (P<0.001). Furthermore, the stratified analysis revealed various impacts based on socioeconomic status and HDL-C levels, with a significant interaction between household income and HDL-C levels (P=0.037). Exclusion of subjects with low HDL-C levels strengthened the association, revealing a significant increase in PSA concentration with higher HDL-C levels (0.50 ng/ml per 1 mmol/l increase, P=0.009). The findings of the present study suggest a nuanced relationship between HDL-C levels, socioeconomic factors, and PSA concentrations, highlighting the potential importance of considering these factors in prostate cancer (Pca) screening and risk assessment. The present study found a positive association between serum HDL-C and PSA concentrations in adult men in the United States without a Pca diagnosis.
Cholelithiasis, or gallstone disease, is a common gastrointestinal disorder with significant global health implications. Recent studies have suggested a potential association between Helicobacter pylori (H. pylori) infection and the development of cholelithiasis. This meta-analysis aims to synthesize the latest evidence on the role of H. pylori as a risk factor for cholelithiasis. A comprehensive literature search was conducted, and studies published between 2018 and 2023 were included. The results indicate a significant association between H. pylori infection and an increased risk of cholelithiasis, with potential mechanisms involving chronic inflammation, altered lipid metabolism, and bile composition changes. This analysis underscores the need for further research to elucidate the causal relationship and explore therapeutic implications.
Rationale: Lipomatous tumors are rare in the pediatric population. Lipomatous tumors may develop at any location throughout the body; however, they are highly uncommon in the retroperitoneal area. Lipomatous tumors represent the predominant category of soft-tissue neoplasms. Only 3 cases of pediatric retroperitoneal lipoma have been reported since 1980. We report a benign retroperitoneal lipomatous tumor and the literature compilation of benign retroperitoneal lesions. Patient concerns: A 2-year-old South Asian female presenting with 13 months of increasing abdominal distention and intermittent fever was referred to our hospital. The child had no trauma or gastrointestinal symptoms like vomiting, diarrhea, or constipation. Diagnoses: An abdominal ultrasound showed a large, echogenic mid-abdomen tumor. The tumor obscured the bowel without calcification or fat necrosis. A color Doppler scan indicated no blood flow in the lesion. The computed tomography scan of the neck, chest, and abdomen with IV contrast showed a well-circumscribed, non-enhancing, heterogeneous hypodense mass from the left hypochondrium to the pelvis on the left abdominal region. The mass measured 18.4 × 14.8 × 13.6 cm, and its Hounsfield units ranged from −66 to −90, indicating adipose tissue. Histopathology showed a benign lipoma made of mature fat cells and thinsultory fibrils with no malignancy, cellular atypia, or necrosis. Interventions: The patient had surgical resection via laparotomy, achieving complete resection with negative margins. Outcomes: The patient was discharged on the 4th day after the procedure, after an uneventful recovery. After 6 weeks, the child was asymptomatic in follow-up. Lessons: The long-term prognosis of the retroperitoneal lipoma among children remains inadequately characterized relative to adults due to a small number of cases. Current literature suggests magnetic resonance imaging, computed tomography scan, and FISH are the most suitable diagnostic options. Extended follow-up is essential in pediatric patients.
Cholelithiasis, or gallstone disease, is a common gastrointestinal disorder with significant global health implications. Recent studies have suggested a potential association between Helicobacter pylori (H. pylori) infection and the development of cholelithiasis. This meta-analysis aims to synthesize the latest evidence on the role of H. pylori as a risk factor for cholelithiasis. A comprehensive literature search was conducted, and studies published between 2018 and 2023 were included. The results indicate a significant association between H. pylori infection and an increased risk of cholelithiasis, with potential mechanisms involving chronic inflammation, altered lipid metabolism, and bile composition changes. This analysis underscores the need for further research to elucidate the causal relationship and explore therapeutic implications.
I’m delighted to share that I’ve been appointed as the Lead Guest Editor for the upcoming Cureus Collection of Surgical Oncology. I warmly …
I am planning to develop several articles focused on recent advances in clinical medicine, surgical oncology, innovations in General surger…
I’m delighted to share that I’ve been appointed as the Lead Guest Editor for the upcoming Cureus Collection of Surgical Oncology. I warmly …
I am planning to develop several articles focused on recent advances in clinical medicine, surgical oncology, innovations in General surger…